RCN3 belongs to the CREC family which contains multiple EF-hand Ca2+-binding proteins localized to the secretory pathway. RCN3 sequence is characterized by the presence of five Arg-Xaa-Xaa-Arg motifs, which represents the target sequence of subtilisin-like proprotein convertases(SPCs). SPCs are a family of seven structurally related serine endoproteases that are involved in the proteolytic activation of proproteins.RCN3 is transiently associated with proPACE4, but not with mature PACE4. Inhibition of PACE4 maturation by a Ca2+ ionophore resulted in accumulation of the proPACE4-RCN-3 complex in cells. It has been proposed that elective and transient association of RCN3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.
RCN3 ELISA Pair sets
RCN3 cDNA Clones
UNQ239/PRO272, RLP49, EF-hand calcium-binding protein RLP49, reticulocabin, reticulocalbin-3 [Homo sapiens]
6030455P07Rik, D530026G20Rik, D7Ertd671e, RLP49, reticulocalbin-3 [Mus musculus]
RCN3 belongs to the CREC family. RCN3 contains 6 EF-hand domains.
|Subcellular location:||Endoplasmic reticulum lumen|
General information above from UniProt