RBP4 Protein & Antibody

Retinol Binding Protein 4, plasma

RBP4 Protein & Antibody

RBP4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
RBP4	Human	RBP4 Protein, Recombinant	10354-H08H
RBP4	Mouse	RBP4 Protein, Recombinant	50170-M08H
RBP4	Canine	RBP4 Protein, Recombinant	70006-D02H
RBP4	Canine	RBP4 Protein, Recombinant	70006-D08H
RBP4	Rat	RBP4 Protein, Recombinant	80008-R08H

  10354-H08H:  Recombinant human RBP4 can bind > 1.0 µM all-trans retinoic acid. Measured by its ability to bind all-trans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.

  50170-M08H:  The 50% binding concentration (BC50) is > 15 µM. Measured by its ability to bind alltrans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.

  80008-R08H:  The 50% binding concentration (BC50) is > 4 µM. Measured by its ability to bind alltrans retinoic acid. The binding of retinoic Acid results in the quenching of Trp fluorescence in RBP4.

RBP4 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human RBP4	WB, ELISA, IHC-P	Mouse Monoclonal Antibody	10354-MM01
Human RBP4	WB, ELISA	RBP4 / PRBP Antibody	10354-MM02
Human RBP4	WB, ELISA, IHC-P	RBP4 Antibody	10354-MM15
Human RBP4	WB, ELISA	Rabbit Polyclonal Antibody	10354-RP01
Human RBP4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10354-RP02
Mouse RBP4	WB, ELISA	RBP4 Antibody, Rabbit PAb	50170-RP01
Mouse RBP4	WB, ELISA	RBP4 Antibody, Rabbit PAb (Antigen Affinity Purified)	50170-RP02
Rat RBP4	WB, ELISA	RBP4 Antibody (Antigen Affinity Purified)	80008-RP02

RBP4 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human RBP4	ELISA	RBP4 ELISA Kit	SEK10354

RBP4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
RBP4	Human	RBP4 cDNA Clone / ORF Clone	HG10354-M
RBP4	Mouse	RBP4 cDNA Clone / ORF Clone	MG50170-M
RBP4	Rat	RBP4 cDNA Clone / ORF Clone	RG80008-G
RBP4	Canine	RBP4 cDNA Clone / ORF Clone	CG70006-G

RBP4 Related Areas

Immunology>>Innate Immunity>>Acute Phase Proteins>>RBP4

RBP4 Alternative Names

RBP4, RBP-4, PRO2222, OTTHUMP00000020115, PRBP, RBP [Homo sapiens]

Rbp4, Rbp-4, PRBP, RBP [Mus musculus]

Rbp4, RBPA, PRBP, RBP [Rattus norvegicus]

RBP4 Background

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

RBP4 Related Studies

1. Yang Q, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436(7049): 356–62.
2. Choi SH, et al. (2008) High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 93(8): 3142-8.
3. Tepper BJ, et al. (2010) Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. Clin Biochem. 43(3): 320-3.