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RBP4 / PRBP Antibody, Rabbit PAb, Antigen Affinity Purified

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Human RBP4 Antibody Product Information
Immunogen:Recombinant Human RBP4 protein (Catalog#10354-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human RBP4 / PRBP (rh RBP4; Catalog#10354-H08H; Met 1-Leu 201; NP_006735.2). RBP4 specific IgG was purified by human RBP4 affinity chromatography.
Human RBP4 Antibody Usage Guide
Specificity:Human RBP4 / PRBP
Application:WB, ELISA, IHC-P, IP

WB: 2-5 μg/ml

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human RBP4. The detection limit for Human RBP4 is 0.00245 ng/well.

IHC-P: 1-3 μg/mL

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human RBP4 Antibody WB Application Image
Human RBP4 Antibody IHC Application Image
RBP4 / PRBP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human RBP4 in human liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
RBP4 / PRBP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human RBP4 in human kidney with rabbit polyclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to proximal tubule.
RBP4 / PRBP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human RBP4 in human pancreas with rabbit polyclonal antibody (2 µg/mL, formalin-fixed paraffin embedded sections).
Human RBP4 Antibody IP Application Image
Other RBP4 Antibody Products
Reactivity: Human  
Application: ELISA  
    10354-MM01-200
    10354-MM01-50
    10354-MM01-100
    200 µg 
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10354-RP01-400
      10354-RP01-100
      10354-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      10354-MM15-200
      10354-MM15-50
      10354-MM15-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10354-MM15-F-50
      10354-MM15-F-100
      50 Tests 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10354-MM15-P-100
      10354-MM15-P-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Mouse  
      Application: IF  ICC/IF  
      • Slide 1
      50170-R008-100
      50170-R008-50
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50170-RP01-100
        50170-RP01-200
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  
        • Slide 1
        50170-RP02-50
        50170-RP02-100
        50170-RP02-200
        50 µg 
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50170-R025-50
          50170-R025-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  WB  
            50170-R001-50
            50170-R001-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50170-R008-F-50
            50170-R008-F-100
            50 Tests 
            100 Tests 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  
              80008-R003-100
              80008-R003-50
              100 µg 
              50 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  
                80008-RP01-200
                80008-RP01-100
                80008-RP01-400
                200 µg 
                100 µg 
                 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  WB  IHC-P  
                • Slide 1
                • Slide 1
                • Slide 1
                80008-RP02-50
                80008-RP02-100
                80008-RP02-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                Reactivity: Cynomolgus  
                Application: ELISA  WB  IHC-P  IP  
                • Slide 1
                • Slide 1
                • Slide 1
                90220-T60-100
                90220-T60-200
                90220-T60-50
                100 µg 
                200 µg 
                50 µg 
                Add to Cart
                Reactivity: Canine  
                Application: ELISA  WB  
                • Slide 1
                70006-T48-50
                70006-T48-100
                70006-T48-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                RBP4 Background

                Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

                Human RBP4 References
              • Yang Q, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436(7049): 356-62.
              • Choi SH, et al. (2008) High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 93(8): 3142-8.
              • Tepper BJ, et al. (2010) Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. Clin Biochem. 43(3): 320-3.
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                Catalog: 10354-RP02-200
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                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"