Anti-RBP4 Antibody

Cat: 10354-RP01
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Anti-RBP4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-RBP4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human RBP4
Immunogen
Recombinant Human RBP4 protein (Catalog#10354-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human RBP4 / PRBP (rhRBP4; Catalog#10354-H08H; Met 1-Leu 201; NP_006735.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-RBP4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-RBP4 Antibody Alternative Names
Anti-RDCCAS Antibody
RBP4 Background Information

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

Full Name
retinol binding protein 4, plasma
References
  • Yang Q, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436(7049): 356-62.
  • Choi SH, et al. (2008) High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 93(8): 3142-8.
  • Tepper BJ, et al. (2010) Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. Clin Biochem. 43(3): 320-3.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-RBP4 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10354-RP02
    Anti-RBP4 Antibody Mouse Monoclonal ELISA(Det) 10354-MM06
    Anti-RBP4 Antibody Mouse Monoclonal ELISA(Cap) 10354-MM11
    Anti-RBP4 Antibody (PE) Mouse Monoclonal FCM 10354-MM15-P
    Anti-RBP4 Antibody Rabbit Polyclonal IHC-P 100808-T08
    Anti-RBP4 Antibody Mouse Monoclonal ELISA,IHC-P 10354-MM15
    Anti-RBP4 Antibody (FITC) Mouse Monoclonal FCM 10354-MM15-F
    Anti-RBP4 Antibody Mouse Monoclonal ELISA 10354-MM01
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