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RBBP4/RBAP48

RBBP4/RBAP48 Protein & Antibody

Entrez Gene Summary for RBBP4/RBAP48


RBBP4 gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for RBBP4 gene. [provided by RefSeq, Sep 2008]

OMIM-Description for RBBP4/RBAP48


The growth suppression function of the retinoblastoma protein (RB1; 614041) is thought to be mediated by RB1 binding to cellular proteins. Qian et al. (1993) showed that RBBP4, which they called RbAp48, is a major protein from HeLa cell lysates that specifically binds to the C terminus of RB1. By screening a HeLa cell cDNA library with a PCR product that was generated using oligonucleotides designed from RBBP4 peptide sequences, they isolated cDNAs encoding RBBP4. The predicted 425-amino acid RBBP4 protein has 30% sequence identity with the S. cerevisiae Msi1 protein, which is presumably a negative regulator of the Ras signal transduction pathway. RBBP4 from HeLa cell lysates has a molecular mass of 48 kD by Western blot analysis. Subcellular fractionation and immunocytochemistry studies showed that RBBP4 is a nuclear protein. Qian and Lee (1995) found that the human and mouse RBBP4 proteins are identical. RBBP4 and RBBP7 (300825) have 89% amino acid identity and contain the same internal trp-asp (WD) repeats. RNase protection analysis detected Rbbp4 expression in all mouse tissues tested, although the levels varied dramatically between different tissues.

.zh=RBBP4/RBAP48


Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.

RBBP4/RBAP48 Alternative Names

CAF-1 subunit C,CAF-I 48 kDa subunit,CAF-I p48,NURF55,RBAP48,RBBP4,RBBP-4, [human]
CAF-1 subunit C,CAF-I 48 kDa subunit,CAF-I p48,mRbAp48,Rbbp4,RBBP-4,RP23-391E6.3,CAF-1 p48 subunit, [mouse]

RBBP4/RBAP48 Related Products

RBBP4/RBAP48 Proteins

Product nameProduct name
Human RBBP4 / RBAP48 Protein (His Tag)

RBBP4/RBAP48 Antibodies

Product nameProduct name
RBBP4 / RBAP48 Antibody, Rabbit PAb, Antigen Affinity Purified

RBBP4/RBAP48 cDNA Clones

Product nameProduct name
Mouse RBBP4/RBAP48 Gene ORF cDNA clone in cloning vectorRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-His tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Myc tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmidHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmidRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmidMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-His tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-HA tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-His tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-HA tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-His tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman RBBP4/RBAP48 Gene ORF cDNA clone in cloning vectorRhesus RBBP4/RBAP48 Gene ORF cDNA clone in cloning vectorMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Flag tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Myc tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagRat RBBP4/RBAP48 Gene ORF cDNA clone in cloning vectorMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-HA tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-HA tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-HA tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-HA tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-His tagRhesus RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-His tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, C-Flag tagHuman RBBP4/RBAP48 Gene ORF cDNA clone expression plasmid, N-Myc tag

RBBP4/RBAP48 ELISA

Product nameProduct name
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