Anti-MMP19 Antibody

Cat: 13912-RP01
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Anti-MMP19 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-MMP19 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human MMP19
Immunogen
Recombinant Human RASI-1 / MMP19 protein (Catalog#13912-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human RASI-1 / MMP19 (rh RASI-1 / MMP19; Catalog#13912-HNAE; Q99542-1; Leu101-Gly256). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-MMP19 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-MMP19 Antibody Alternative Names
Anti-MMP18 Antibody;Anti-RASI-1 Antibody
MMP19 Background Information

MMP19, also known as RASI-1, is a member of the peptidase M10A family. It contains 4 hemopexin-like domains and is expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. It is a matrix metalloproteinase (MMP). Proteins of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP19 may play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.

Full Name
matrix metallopeptidase 19
References
  • Cossins J., et al.,(1996), Identification of MMP-18, a putative novel human matrix metalloproteinase. Biochem. Biophys. Res. Commun. 228:494-498.
  • Pendas A.M., et al., (1997), Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution.J. Biol. Chem. 272:4281-4286.
  • Kolb C., et al.,(1997), The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient.Immunol. Lett. 57:83-88.
  • Product Description Host Clonality Application Catalog# (PDF)
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