RAC1 Protein

Ras-related C3 botulinum toxin substrate 1

RAC1 Products

RAC1 Protein, Recombinant

Molecule	Species	Description	Cat. No
RAC1	Human	RAC1 Protein, Recombinant	10535-H09B

RAC1 cDNA Clone

Molecule	Species	Description	Cat. No
RAC1	Human	Homo sapiens RAC1 cDNA Clone(NM_006908.4)	HG10535-M
RAC1	Mouse	Mouse RAC1/MIG5 cDNA Clone / ORF Clone	MG50789-G

RAC1 Related Areas

Stem Cell>>Neural Stem Cell (NSC)>>Neural Crest Stem Cell>>Neural Crest Effector>>RAC1

RAC1 Alternative Names

RAC1, MIG5, MGC111543, TC-25, p21-Rac1 [Homo sapiens]

Rac1, AL023026, D5Ertd559e [Mus musculus]

RAC1 Background

RAC1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. RAC1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophage. RAC1 is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. RAC1's isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

RAC1 Related Studies

1. Kogai T, et al.. (2012) Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. J Biol Chem. 287(5):3292-300.
2. Osborn-Heaford HL, et al. (2012) Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem. 287(5):3301-12.
3. Chang MH, et al. (2012) Prognostic role of integrin β1, E-cadherin, and rac1 expression in small cell lung cancer. APMIS. 120(1):28-38.
4. Osborn-Heaford HL, et al. (2012) Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem. 287(5):3301-12.