All Rab2 reagents are produced in house and quality controlled, including 30 Rab2 Gene, 1 Rab2 Protein, 2 Rab2 qPCR. All Rab2 reagents are ready to use.
Recombinant Rab2 proteins are expressed by E. coli with fusion tags as N-His.
Rab2 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Rab2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and independent predictor of disease recurrence in BC patients. Thus, RAB2A is a novel trafficking determinant essential for regulation of a mesenchymal invasive program of BC dissemination.At the cellular levels, RAB2A controls both canonical polarized Golgi-to-Plasma membrane trafficking of the junctional protein E-cadherin, and post-endocytic trafficking of the membrane-bound metalloprotease, MT1-MMP.