RAB1B (Protein | Antibody | cDNA Clone | ELISA Kit)

All RAB1B reagents are produced in house and quality controlled, including 43 RAB1B Gene, 1 RAB1B Lysate, 1 RAB1B Protein, 2 RAB1B qPCR. All RAB1B reagents are ready to use.

RAB1B Protein (1)

RAB1B cDNA Clone (43)

RAB1B Lysate (1)

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RAB1B Related Research Area

RAB1B Background

RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells.Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermore, low RAB1B expression correlated with poor prognosis in breast cancer patients.RAB1B acts as a metastasis suppressor in TNBC by regulating the TGF-beta/SMAD signaling pathway and RAB1B may serve as a novel biomarker of prognosis and the response to anti-tumor therapeutics for patients with TNBC.