All RAB1B reagents are produced in house and quality controlled, including 43 RAB1B Gene, 1 RAB1B Lysate, 1 RAB1B Protein, 2 RAB1B qPCR. All RAB1B reagents are ready to use.
Recombinant RAB1B proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc.
RAB1B cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each RAB1B of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells.Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermore, low RAB1B expression correlated with poor prognosis in breast cancer patients.RAB1B acts as a metastasis suppressor in TNBC by regulating the TGF-beta/SMAD signaling pathway and RAB1B may serve as a novel biomarker of prognosis and the response to anti-tumor therapeutics for patients with TNBC.