R-Cadherin Protein & Antibody (CDH4)

Retinal-Cadherin (Cadherin 4)

R-Cadherin Products

R-Cadherin Protein, Recombinant

Molecule	Species	Description	Cat. No
R-Cadherin/CDH4	Human	R-Cadherin/CDH4 Protein, Recombinant	10230-H08H

  10013-HNAE: Human CAD4 immobilized at 0.8 µg/mL, 100 µL/well will mediate > 20% C6 cell adhesion. Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells.

R-Cadherin Antibody

Molecule	Application	Description	Cat. No
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb	10230-RP01
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)	10230-RP02

R-Cadherin Alternative Names

R-Cadherin, CDH4, CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD [Homo sapiens]

R-Cadherin, Cdh4, RP23-23G3.1, AW120700, Rcad [Mus musculus]

R-Cadherin Related Areas

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>R-Cadherin/CDH4

Immunology>>Adhesion Molecule>> Cadherin>>R-Cadherin/CDH4

R-Cadherin Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	E-Cadherin/CDH1 Protein, Recombinant
E-Cadherin/CDH1	Mouse	E-Cadherin/CDH1 Protein, Recombinant
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD144/CDH5 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule	Applications	Description //For Detailed Info. and Price------CLICK!
Human E-Cadherin/CDH1/CD324	WB, ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse VE-Cadherin/CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	Homo sapiens E-Cadherin/CDH1 cDNA Clone(NM_004360.3)
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD144/CDH5 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
KSP-Cadherin/CDH16	Human	Homo sapiens Cadherin-16/CDH16 cDNA Clone(NM_004062.2)
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone

R-Cadherin Background

Classical cadherins are the transmembrane proteins of the adherens junction and mediate cell-cell adhesion via homotypic interactions in the extracellular space. Cadherin switching has also been implicated in tumorigenesis, particularly in metastasis. Recently, cadherins have been shown to be engaged in cellular activities other than adhesion, including motility, invasion, and signaling. Cadherin 4 (CDH4), also known as R-cadherin (retinal), CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-dependent adhesion molecule and a type I transmembrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. CDH4 is thought to play an important role during brain segmentation and neuronal outgrowth, and also exerts critical actions in kidney and muscle development. R-Cadherin is expressed in vascular smooth muscle, pancreatic β-cells, thyroid follicular cells, sensory neurons of the dorsal root ganglia, and, possibly, astrocytes and endothelium of the retina. Its expression inhibits myogenesis and induces myoblast transformation through Rac1 activation. Additionally, R-Cadherin plays an important role in the formation of striated muscle and possibly also of epithelia.

R-Cadherin Related Studies

1. Rosenberg P, et al. (1997) A potential role of R-cadherin in striated muscle formation. Dev Biol. 187(1): 55-70.
2. Johnson E, et al. (2004) R-cadherin influences cell motility via Rho family GTPases. J Biol Chem. 279(30): 31041-9.
3. Kucharczak J, et al. (2008) R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase. Cancer Res. 68(16): 6559-68.