Anti-R-Cadherin Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human CDH4 protein (Catalog#10230-H08H)
Produced in rabbits immunized with purified, recombinant Human CDH4 extracellular domain (rh CDH4; Catalog#10230-H08H; NP_001785.2; Met 1-Ala 734). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-R-Cadherin Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-R-Cadherin Antibody Alternative Names
Anti-CAD4 Antibody;Anti-R-CAD Antibody;Anti-RCAD Antibody
R-Cadherin Background Information
The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-dependent adhesion molecule and a type I transmembrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. CDH4 is thought to play an important role during brain segmentation and neuronal outgrowth, and also exerts critical actions in kidney and muscle development. CDH4 is expressed in vascular smooth muscle, pancreatic β-cells, thyroid follicular cells, sensory neurons of the dorsal root ganglia, and, possibly, astrocytes and endothelium of the retina. As a classic cadherin, CDH4 forms both homodimers and heterodimers with N-cadherin. The extracellular region of human CDH4 is 96% aa identical to that of mouse CDH4.
cadherin 4, type 1, R-cadherin (retinal)
Suzuki, S. et al., 1991, Cell Regul. 2: 261-270. Matsunami, H. et al., 1993, J. Cell Sci. 106: 401-409. Tanihara, H. et al.,1995, Cell Adhes. Commun. 2 (1): 15-26. Shan, W-S., et al., 2000, J. Cell Biol. 148: 579-590. Fagman, H. et al, 2003, Endocrinology. 144: 3618-3624. Koch, A.W. et al., 2004, Cell. Mol. Life Sci. 61: 1884-1895.