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>Purine nucleoside phosphorylase / PNP Antibody
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Purine nucleoside phosphorylase / PNP Antibody Datasheet
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|Detection limit is 0.00975 ng/well in ELISA|
Purine nucleoside phosphorylase / PNP Antibody Product Information
Recombinant Human Purine nucleoside phosphorylase / PNP protein (Catalog#12097-H08E)
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
This antibody was obtained from a rabbit immunized with purified, recombinant Human Purine nucleoside phosphorylase / PNP (rh Purine nucleoside phosphorylase / PNP; Catalog#12097-H08E; P00491; Met 1-Ser 289).
Purine nucleoside phosphorylase / PNP Antibody Usage Guide
Human Purine nucleoside phosphorylase / PNP
|Western blot :||
This antibody can be used at 2-5 μg/mL with the appropriate secondary reagents to detect Human PNP in WB.
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human PNP. The detection limit for Human PNP is approximately 0.00975 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Purine nucleoside phosphorylase / PNP Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Purine Nucleoside Phosphorylase/PNP||Human||Purine nucleoside phosphorylase/PNP Protein, Recombinant||12097-H08E|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human Purine Nucleoside Phosphorylase/PNP||ELISA||Purine nucleoside phosphorylase / PNP Antibody||12097-R103|
Purine nucleoside phosphorylase / PNP Antibody Background
Purine nucleoside phosphorylase, also known as Inosine phosphorylase and PNP, is a cytoplasm protein which belongs to thePNP / MTAP phosphorylase family. Purine nucleoside phosphorylase / PNP is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides. PNP is specific for purine nucleosides in the beta-configuration and exhibits a strong preference for purines containing a 6-keto group and ribosyl-containing nucleosides relative to the corresponding analogues. Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. PNP is a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNP deficiency) which leads to a severe T-cell immuno-deficiency with neurologic disorder in children.
- de Azevedo,W.F.et al., 2003, Biochem Biophys Res Commun. 312 (3): 767-72.
- Canduri,F. et al., 2005, Acta Crystallogr D Biol Crystallogr. 61 (7): 856-62.
- Perera,G.K. et al., 2005, Clin Exp Dermatol. 30 (1): 27-9.