Protein C Inhibitor

Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Protein C inhibitor inactivates serine proteases by binding irreversibly to their serine activation site. Protein C inhibitor is involved in the regulation of intravascular and extravascular proteolytic activities. Protein C inhibitor plays hemostatic roles in the blood plasma. Protein C inhibitor acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Protein C inhibitor acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, protein C inhibitor inactivates several serine proteases implicated in the reproductive system. Protein C inhibitor inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Protein C inhibitor inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Protein C inhibitor inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, it inhibits urinary-type plasminogen activator and kallikrein activities. Protein C inhibitor inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. It nhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Protein C inhibitor may also play a non-inhibitory role in seminal plasma and urine as an hydrophobic hormone carrier by its binding to retinoic acid.

Protein C Inhibitor Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Serpin Superfamily>>Protein C Inhibitor/SerpinA5

Immunology>>Innate Immunity>>Coagulation>>Protein C Inhibitor/SerpinA5

Cardiovascular>>Coagulation>>Protein C Inhibitor/SerpinA5

Protein C Inhibitor Alternative Names

Protein C Inhibitor, SERPINA5, PAI3, PCI, PLANH3, PROCI [Homo sapiens]

Protein C Inhibitor, Serpina5, 4933415L04, PAI-3, Pci [Mus musculus]

Summaries for Protein C Inhibitor

Wikipedia summary for Protein C Inhibitor:

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C (an anticoagulant).
An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.[

Human Protein C Inhibitor Protein General Information

 

• Protein names: Protein C inhibitor, Short name=PCI
• Sequence length: 406 AA.
• Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
• Sequence similarities: Protein C inhibitor belongs to the serpin family.
• Post-translational modification: N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.
• Subunit structure: Protein C inhibitor forms protease inhibiting heterodimers in extracellular body fluids with serine proteases such as activated protein C/coagulation factor V/F5, acrosin/ACR, chymotrypsinogen B/CTRB1, prothrombin/F2, factor Xa/F10, factor XI/F11, kallikrein/KLKB1, tissue kallikrein, trypsin/PRSS1, prostate specific antigen/KLK3, tissue plasminogen activator/PLAT and urinary plasminogen activator/PLAU. Protein C inhibitor forms membrane-anchored serine proteases inhibiting heterodimers with TMPRSS7 and TMPRSS11E. Interacts with SEMG2.
• Subcellular location: Secreted › extracellular space. Note: Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
• Tissue specificity: Protein C inhibitor is predominantly expressed in the epithelium of seminal vesicles.Protein C is expressed in the proximal tubular epithelium of the kidney. Protein C inhibitor is expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Protein C inhibitor is expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Protein C inhibitor is expressed in spermatozoa. Protein C inhibitor present in very high concentration in seminal plasma. Protein C inhibitor presents in high concentration in plasma, synovial and Graaf follicle fluids. Protein C inhibitor presents resent in low concentration in breast milk and in amniotic fluids. Protein C inhibitor presents in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Protein C inhibitor is xpressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
• Involvement in disease: Its inhibitory activity is greatly enhanced in the presence of glycosaminoglycans, heparin, thrombomodulin and phospholipids vesicles.

General information above from UniProt

Function for Protein C Inhibitor Protein

UniProtKB:

Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Protein C inhibitor inactivates serine proteases by binding irreversibly to their serine activation site. Protein C inhibitor is involved in the regulation of intravascular and extravascular proteolytic activities. Protein C inhibitor plays hemostatic roles in the blood plasma. Protein C inhibitor acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Protein C inhibitor acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, protein C inhibitor inactivates several serine proteases implicated in the reproductive system. Protein C inhibitor inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Protein C inhibitor inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Protein C inhibitor inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, it inhibits urinary-type plasminogen activator and kallikrein activities. Protein C inhibitor inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. It nhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Protein C inhibitor may also play a non-inhibitory role in seminal plasma and urine as an hydrophobic hormone carrier by its binding to retinoic acid.

Genatlas:

• Protein C inhibitor inhibits activated protein C as well as plasminogen activators