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SerpinA5 Antibody, Rabbit PAb

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    Human SerpinA5 Antibody Product Information
    Immunogen:Recombinant Human SerpinA5 protein (Catalog#10309-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Human SerpinA5 (rhSerpinA5; Catalog#10309-H08H; aa 1-406; NP_000615.3). Total IgG was purified by Protein A affinity chromatography.
    Other SerpinA5 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10309-RP03-50
      10309-RP03-200
      10309-RP03-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10309-MM01-50
        10309-MM01-200
        10309-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10309-R110-50
          10309-R110-100
          50 µg 
          100 µg 
          Add to Cart
          Protein C Inhibitor Background

          Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

          Human Protein C Inhibitor References
        • Alireza, R. et al., 1995, J. Biol. Chem. 270: 25336-25339.
        • Silverman, G.A. et al., 2001, J. Biol. Chem. 276: 33293-33296.
        • Malleier, J.M. et al., 2007, Blood. 109: 4769-4776.
        • Asanuma, K. et al., 2007, Int. J. Cancer. 121: 955-965.
        • Hayashi, T. et al., 2007, J. Thromb. Haemost. 5: 1477-1485.
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          Size / Price
          Catalog: 10309-RP02-400
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"