Anti-PCI Antibody (Mouse Monoclonal antibody) General Information
Reacts with: Human
Recombinant Human SerpinA5 protein (Catalog#10309-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant human SerpinA5 (rhSerpinA5; Catalog#10309-H08H; aa 1-406; NP_000615.3). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #4H10A7G6C1
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PCI Antibody (Mouse Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-PCI Antibody Alternative Names
Anti-PAI-3 Antibody;Anti-PAI3 Antibody;Anti-PCI Antibody;Anti-PCI-B Antibody;Anti-PLANH3 Antibody;Anti-PROCI Antibody
PCI Background Information
Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Alireza, R. et al., 1995, J. Biol. Chem. 270: 25336-25339. Silverman, G.A. et al., 2001, J. Biol. Chem. 276: 33293-33296. Malleier, J.M. et al., 2007, Blood. 109: 4769-4776. Asanuma, K. et al., 2007, Int. J. Cancer. 121: 955-965. Hayashi, T. et al., 2007, J. Thromb. Haemost. 5: 1477-1485.