Anti-PCI Antibody

Cat: 10309-RP03
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Anti-PCI Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PCI Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PCI
Immunogen
Human cell-derived rhSerpinA5 (Catalog#10309-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SerpinA5 (rhSerpinA5; Catalog#10309-H08H; aa 1-406; NP_000615.3). SerpinA5 specific IgG was purified by human SerpinA5 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PCI Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PCI Antibody Alternative Names
Anti-PAI-3 Antibody;Anti-PAI3 Antibody;Anti-PCI Antibody;Anti-PCI-B Antibody;Anti-PLANH3 Antibody;Anti-PROCI Antibody
PCI Background Information

Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Research Areas
References
  • Alireza, R. et al., 1995, J. Biol. Chem. 270: 25336-25339.
  • Silverman, G.A. et al., 2001, J. Biol. Chem. 276: 33293-33296.
  • Malleier, J.M. et al., 2007, Blood. 109: 4769-4776.
  • Asanuma, K. et al., 2007, Int. J. Cancer. 121: 955-965.
  • Hayashi, T. et al., 2007, J. Thromb. Haemost. 5: 1477-1485.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PCI Antibody Rabbit Monoclonal ELISA 10309-R110
    Anti-PCI Antibody Mouse Monoclonal ELISA 10309-MM01
    Anti-PCI Antibody Rabbit Polyclonal ELISA 10309-RP02
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