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Protease & Regulator

Sino Biological offers quality products for study of proteases and their regulators, including recombinant proteins, antibodies (rabbit MAb, mouse MAb, rabbit PAb), ELISA kits, and gene cDNA clones.

Product CategoriesProteinsAntibodiesELISA KitscDNA Clones
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    Protease & Regulator Background

    A protease is an enzyme that conducts proteolysis by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain forming the protein. The activity of proteolysis can be a destructive change, abolishing a protein's function or digesting it to its principal components; it can be an activation of a function, or it can be a signal in a signaling pathway. Based upon their substrate specificity, proteases are currently classified into six groups: aspartate proteases, serine proteases, threonine proteases, cysteine proteases, metalloproteases, and gutamic acid proteases. Alternatively, proteases can be classified by the optimal pH in which they are active: acid proteases, neutral proteases and alkaline proteases. The activity of proteases can be inhibited by protease inhibitors. Many naturally occurring protease inhibitors are proteins, such as the serpin superfamily and lipocalin proteins. In some viruses, such as HIV, proteases are proven to control viral replication. Protease inhibitors are developed as antivirus drugs.

    Protease & Regulator References

      1. Tsantrizos YS. (2009) TMC-435, an NS3/4A protease inhibitor for the treatment of HCV infection. Curr Opin Investig Drugs. 10(8):871-81.
      2. Peters T, et al. (2009) Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol. 158(4):1017-33.
      3. Agard NJ, et al. (2009) Methods for the proteomic identification of protease substrates. Curr Opin Chem Biol. 13(5-6):503-9.
      4. Soh UJ, et al. (2010) Signal transduction by protease-activated receptors. Br J Pharmacol. 160(2):191-203.