Anti-Prostatic Acid Phosphatase Antibody

Cat: 10959-R060
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All Prostatic Acid Phosphatase Reagents
Anti-Prostatic Acid Phosphatase Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Prostatic Acid Phosphatase Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Prostatic Acid Phosphatase
Has cross-reactivity in ELISA with Mouse ACPP
No cross-reactivity in ELISA with Human ACP5
Immunogen
Recombinant Human Prostatic Acid Phosphatase / ACPP protein (Catalog#10959-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Prostatic Acid Phosphatase / ACPP (rh Prostatic Acid Phosphatase / ACPP; Catalog#10959-H08H; NP_001127666.1; Met1-Lys382).
Source
Monoclonal Rabbit IgG Clone #060
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Prostatic Acid Phosphatase Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Prostatic Acid Phosphatase Antibody Alternative Names
Anti-5'-NT Antibody;Anti-ACP-3 Antibody;Anti-ACP3 Antibody;Anti-PAP Antibody
Prostatic Acid Phosphatase Background Information

Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase synthetized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.

Full Name
acid phosphatase, prostate
References
  • Hassan MI, et al. (2010) Structural and functional analysis of human prostatic acid phosphatase. Expert Rev Anticancer Ther. 10(7): 1055-68.
  • Chuang TD, et al. (2010) Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth. J Biol Chem. 285(31): 23598-606.
  • Larsen RS, et al. (2009) A high throughput assay to identify small molecule modulators of prostatic acid phosphatase. Curr Chem Genomics. 3: 42-9.
  • Zimmermann H. (2009) Prostatic acid phosphatase, a neglected ectonucleotidase. Purinergic Signal. 5(3): 273-5.
  • Wang Y, et al. (2005) Prostatic acid phosphatase as a target molecule in specific immunotherapy for patients with nonprostate adenocarcinoma. J Immunother. 28(6): 535-41.
  • Veeramani S, et al. (2005) Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer. Endocr Relat Cancer. 12(4): 805-22.
  • Ostrowski WS, et al. (1994) Human prostatic acid phosphatase: selected properties and practical applications. Clin Chim Acta. 226(2): 121-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Monoclonal ELISA 51018-R202
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Polyclonal ELISA 51018-T16
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Polyclonal WB,ELISA,IHC-P 51018-T56
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Monoclonal ELISA(Cap) 51018-R019
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Monoclonal ELISA,ELISA(Det) 51018-R205
    Anti-Prostatic Acid Phosphatase Antibody Mouse Monoclonal ELISA 10959-MM03
    Anti-Prostatic Acid Phosphatase Antibody Mouse Monoclonal ELISA 10959-MM06
    Anti-Prostatic Acid Phosphatase Antibody Rabbit Monoclonal ELISA 10959-R004
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