Anti-Prostasin Antibody

Cat: 10287-R107
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Anti-Prostasin Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Prostasin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Prostasin
Immunogen
Recombinant Human PRSS8 protein (Catalog#10287-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Prostasin / PRSS8 (rh PRSS8; Catalog#10287-H08H; NP_002764.1; Ala 30-Arg 322).
Source
Monoclonal Rabbit IgG Clone #107
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Prostasin Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Prostasin Antibody Alternative Names
Anti-CAP1 Antibody;Anti-PROSTASIN Antibody
Prostasin Background Information

Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

Full Name
protease, serine, 8
References
  • Yu J.X., et al.,(1995), Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J. Biol. Chem. 270:13483-13489.
  • Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
  • Martin J., et al.,(2004), The sequence and analysis of duplication-rich human chromosome 16.Nature 432:988-994.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Prostasin Antibody Rabbit Polyclonal WB,ELISA,IHC-P 50120-T56
    Anti-Prostasin Antibody Rabbit Polyclonal ELISA,IHC-P 10287-RP02
    Anti-Prostasin Antibody Rabbit Monoclonal WB 10287-R017
    Anti-Prostasin Antibody Rabbit Polyclonal ELISA 10287-T16
    Anti-Prostasin Antibody Rabbit Polyclonal ELISA 10287-RP01
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