Prolactin Receptor Protein & Antibody (PRLR)

Prolactin Receptor Products

Prolactin Receptor Protein, Recombinant

Molecule	Species	Description	Cat. No
Prolactin Receptor/PRLR	Human	Prolactin Receptor/PRLR  Protein, Recombinant	10278-H08H
Prolactin Receptor/PRLR	Mouse	Prolactin Receptor/PRLR/Fc Protein, Recombinant	50457-M03H

Prolactin Receptor  Antibody

Molecule	Application	Description	Cat. No
Human Prolactin Receptor/PRLR	WB	Prolactin Receptor/PRLR Antibody, Rabbit Mab	10278-R101
Human Prolactin Receptor/PRLR	ELISA	Prolactin Receptor/PRLR Antibody, Rabbit Mab	10278-R204
Human Prolactin Receptor/PRLR	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10278-RP01
Human Prolactin Receptor/PRLR	WB, ELISA	Rabbit Polyclonal Antibody	10278-RP02

Prolactin Receptor ELISA Kit

Molecule	Application	Description	Cat. No
Human Prolactin Receptor/PRLR	ELISA	Prolactin Receptor/PRLR ELISA Kit	SEK10278

Prolactin Receptor cDNA Clone

Molecule	Species	Description	Cat. No
Prolactin Receptor/PRLR	Human	Homo sapiens Prolactin Receptor/PRLR cDNA Clone(NM_000949.2)	HG10278-M
Prolactin Receptor/PRLR	Mouse	Mus musculus Prolactin Receptor/PRLR cDNA Clone	MG50457-M
Prolactin Receptor/PRLR	Rat	Rat Prolactin Receptor/PRLR cDNA Clone / ORF Clone	RG80062-M

Prolactin Receptor Alternative Names

Prolactin Receptor, PRLR, hPRLrI [Homo sapiens]

Prolactin Receptor, Prlr, AI987712, Pr-1, Pr-3, Prlr-rs1 [Mus musculus]

Prolactin Receptor Background

Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type â…  cytokine receptor superfamily, and contains two fibronectin type-â…¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.

Prolactin Receptor Related Studies

1. Bole-Feysot C, et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-68.
2. Goffin V, et al. (1999) From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 15(3-5): 189-201.
3. Li Y, et al. (2006) Stabilization of prolactin receptor in breast cancer cells. Oncogene. 25(13): 1896-902.
4. Shao R, et al. (2008) Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice. Biol Reprod. 79(4): 748-57.