Anti-Transthyretin Antibody

Cat: 12091-R003
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Anti-Transthyretin Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Transthyretin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Transthyretin
Immunogen
Recombinant Human TTR / Prealbumin / Transthyretin protein (Catalog#12091-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Prealbumin / Transthyretin / TTR (rh Prealbumin / Transthyretin / TTR; Catalog#12091-H08H; NP_000362.1; Met 1-Glu 147).
Source
Monoclonal Rabbit IgG Clone #003
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Transthyretin Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Transthyretin Antibody Alternative Names
Anti-CTS Antibody;Anti-CTS1 Antibody;Anti-HEL111 Antibody;Anti-HsT2651 Antibody;Anti-PALB Antibody;Anti-TBPA Antibody
Transthyretin Background Information

Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Full Name
transthyretin
References
  • Westermark P, et al. (1990) Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc Natl Acad Sci U S A. 87(7): 2843-5.
  • Colon W, et al. (1992) Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31(36): 8654-60.
  • Hammarstrm P, et al. (2003) Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science. 299(5607): 713-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Transthyretin Antibody Rabbit Polyclonal ELISA 12091-RP02
    Anti-Transthyretin Antibody Rabbit Polyclonal ELISA 12091-RP01
    Anti-Transthyretin Antibody Rabbit Polyclonal ELISA 12091-T16
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