Podoplanin

Podoplanin may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, podoplanin induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Podoplanin is required for normal lung cell proliferation and alveolus formation at birth. Podoplanin induces platelet aggregation. Podoplanin does not have any effect on folic acid or amino acid transport. Podoplanin does not function as a water channel or as a regulator of aquaporin-type water channels.

Podoplanin Related Areas

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>Podoplanin/PDPN

Cancer>>Cancer Stem Cell (CSC)>>Podoplanin/PDPN

Podoplanin Alternative Names

Podoplanin, PDPN, CTA-520D8.1, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2 [Homo sapiens]

Podoplanin, Pdpn, RP23-348F1.2, Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha [Mus musculus]

Summaries for Podoplanin

Entrez Gene summary for Podoplanin:

PDPN gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Wikipedia summary for Podoplanin:

Podoplanin is a protein that in humans is encoded by the PDPN gene.
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.

Human Podoplanin Protein General Information

 

• Protein names: Podoplanin
• Sequence length: 162 AA.
• Domain: Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the podoplanin family.
• Post-translational modification: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. Ref.2 Ref.6 Ref.11 The N-terminus is blocked.
• Sequence caution: The sequence AAM73655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
  The sequence AAO22143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
  The sequence BAC11550.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
  The sequence BAC11557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
  The sequence BAG35495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
• Subcellular location: Membrane; Single-pass type I membrane protein . Cell projection › filopodium membrane; Single-pass type I membrane protein . Cell projection › lamellipodium membrane; Single-pass type I membrane protein . Cell projection › microvillus membrane; Single-pass type I membrane protein . Cell projection › ruffle membrane; Single-pass type I membrane protein . Note: Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles
• Tissue specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

General information above from UniProt

Function for Podoplanin Protein

UniProtKB:

Podoplanin may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, podoplanin induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Podoplanin is required for normal lung cell proliferation and alveolus formation at birth. Podoplanin induces platelet aggregation. Podoplanin does not have any effect on folic acid or amino acid transport. Podoplanin does not function as a water channel or as a regulator of aquaporin-type water channels.

Genatlas:

• Podoplanin is mucine-type glycoprotein, may be a differentiation antigen and influenza-virus receptor
• Podoplanin may be a marker of lung injury
• Podoplanin is platelet aggregation-inducing factor expressed in colorectal tumors
• Podoplanin is specific marker of lymphatic endothelium
• Podoplanin promotes directional persistence of motility in epithelial cells, a feature that requires CD44, and both molecules cooperate to promote directional migration in squamous stratified epithelia (SCCs) cells