Platelet-derived Growth Factor (PDGF) in Cancer

A Role for Platelet-derived Growth Factor (PDGF) in Angiogenesis

Platelet-derived growth factor (PDGF) plays a critical role in the regulation of mesenchymal cell migration and proliferation. Aberrant expression of PDGF and its receptor is often associated with a variety of disorders including atherosclerosis, fibroproliferative diseases of lungs, kidneys and joints, and neoplasia. PDGF may exert its function in white matter participating either in regeneration of damaged axons or in glial scar formation. PDGF-BB and its receptor expressed on microvessel endothelial cells might be involved in angiogenesis after stroke.

Platelet-Derived Growth Factor (PDGF) in Cancer

PDGF plays a significant role in blood vessel formation (angiogenesis), the growth of blood vessels from already-existing blood vessel tissue. Uncontrolled angiogenesis is a characteristic of cancer. PDGF contributes to cancer development and progression by both autocrine and paracrine signaling mechanisms.

Platelet-derived Growth Factor (PDGF) in Cancer Related Studies

    1. Yu J, et al. (2003) Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol.36(1):49-59..
    2. S. Ariad, et al. (1991) Platelet-derived growth factor (PDGF) in plasma of breast cancer patients: Correlation with stage and rate of progression.Breast Cancer Research and Treatment 20(1) : 11-7.
    3. Shima AHR, et al. (2010) Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. PNAS. 107(25): 11307-12.
    4. Abdollahi A, et al. (2005) Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med. 201(6):925-35.
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