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>Platelet-Derived Growth Factor (PDGF) & Receptor
Platelet-Derived Growth Factor (PDGF) & Receptor
Platelet-derived growth factor acts through a cell surface receptor, PDGFR, which is a receptor tyrosine kinase. Two types of PDGFRs have been identified: alpha type (PDGFRA) and beta type (PDGFRB) PDGFRs.More
Inhibition of the PDGF signal pathway results in loss of pericytes and a reduction in vessel density in the neovascularized cornea that correlates with reduced expression of PDGF, ang1/2, and VEGF mRNA. More
Platelet-derived Growth Factor (PDGF) signaling network consists of four ligands, PDGFA-D, and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers. More
PDGF contributes to cancer development and progression by both autocrine and paracrine signaling mechanisms. More
Human platelet-derived growth factor (PDGF) was purified from lysates of clinically outdated human platelets by a direct procedure that allowed the recovery of active PDGF from stained sodium dodecyl sulfate/polyacrylamide gels. This technique enabled the identification and purification to homogeneity of two active PDGF polypeptides, and with a molecular weight of about 35,000 (PDGF-I) and the other with a molecular weight of about 32,000 (PDGF-II). Reduced PDGF-I produced two inactive subunits, with molecular weights of about 15,000 and 18,000. Reduced PDGF-II also produced two inactive subunits, with molecular weights of about 15,000 and 16,000. It is possible that PDGF-II derives from proteolytic cleavage of PDGF-I.
Platelet-derived growth factor (PDGF) factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers.
Fig 1. Structure of the PDGF-B:PDGFRβ complex. (A) Side view of the ribbon model of the complex, with the PDGF-B protomers in green and blue, and the PDGFRβ protomers in pink and orange. The N-linked glycans attached to PDGFRβ are depicted as sticks. (B) Top view of the PDGF-B:PDGFRβ complex in surface representation.
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