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Platelet-Derived Growth Factor (PDGF) & Receptor

Sino biological offers a comprehensive set of tools for platelet-derived growth factor (PDGF) related research, including recombinant proteins, antibodies (rabbit mAbs, mouse mAbs, rabbit pAbs), ELISA kits, and ORF cDNA clones. Platelet-derived growth factors (PDGFs) constitute a group of growth factors that play a significant role in blood vessel formation, and the growth of blood vessels from already existing blood vessel tissue. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles in embryonic development, cell proliferation, cell migration, and angiogenesis. Like many other growth factors that have been linked to disease, platelet-derived growth factor has provided a market for protein receptor antagonists to treat disease.

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Platelet-Derived Growth Factor (PDGF) & Receptor Related Products Index

    Platelet-Derived Growth Factor (PDGF) & Receptor Related Products by Product Type

    Platelet-Derived Growth Factor (PDGF) & Receptor Background

    Platelet-derived growth factors (PDGFs) constitute a group of growth factors that play a significant role in blood vessel formation (angiogenesis), and the growth of blood vessels from already existing blood vessel tissue. There are five different isoforms of PDGF, including PDGF-A, PDGF-B, PDGF-C, PDGF-D and an AB heterodimer PDGF-AB. Platelet-derived growth factor acts through a cell surface receptor, PDGFR, which is a receptor tyrosine kinase. Two types of PDGFRs have been identified: alpha type (PDGFRA) and beta type (PDGFRB) PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB while the beta type PDGFR binds with high affinity to PDGF-BB and PDGF-AB. Upon activation by PDGF, PDGFR dimerise and activate signaling pathway involving gene expression, cell cycle and many other processes. Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF also has important roles in embryonic development, cell proliferation, cell migration, and angiogenesis. Like many other growth factors that have been linked to disease, platelet-derived growth factor has provided a market for protein receptor antagonists to treat disease.

    Platelet-derived Growth Factor (PDGF) Receptors
    Platelet-derived growth factor acts through a cell surface receptor, PDGFR, which is a receptor tyrosine kinase. Two types of PDGFRs have been identified: alpha type (PDGFRA) and beta type (PDGFRB) PDGFRs. Learn More.

    Platelet-derived Growth Factor (PDGF) Inhibitor
    Inhibition of the PDGF signal pathway results in loss of pericytes and a reduction in vessel density in the neovascularized cornea that correlates with reduced expression of PDGF, ang1/2, and VEGF mRNA. Learn More.

    Platelet-derived Growth Factor (PDGF) Signaling Pathway
    Platelet-derived Growth Factor (PDGF) signaling network consists of four ligands, PDGFA-D, and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers. Learn More.

    Platelet-derived Growth Factor (PDGF) in Cancer
    PDGF contributes to cancer development and progression by both autocrine and paracrine signaling mechanisms. Learn More.

    Platelet-derived Growth Factor (PDGF) Molecular Weight
    Human platelet-derived growth factor (PDGF) was purified from lysates of clinically outdated human platelets by a direct procedure that allowed the recovery of active PDGF from stained sodium dodecyl sulfate/polyacrylamide gels. This technique enabled the identification and purification to homogeneity of two active PDGF polypeptides, and with a molecular weight of about 35,000 (PDGF-I) and the other with a molecular weight of about 32,000 (PDGF-II). Reduced PDGF-I produced two inactive subunits, with molecular weights of about 15,000 and 18,000. Reduced PDGF-II also produced two inactive subunits, with molecular weights of about 15,000 and 16,000. It is possible that PDGF-II derives from proteolytic cleavage of PDGF-I.

    Platelet-derived Growth Factor (PDGF) Structure
    Platelet-derived growth factor (PDGF) factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers.

    Platelet-derived Growth Factor (PDGF) Structure

    Fig 1. Structure of the PDGF-B:PDGFRβ complex. (A) Side view of the ribbon model of the complex, with the PDGF-B protomers in green and blue, and the PDGFRβ protomers in pink and orange. The N-linked glycans attached to PDGFRβ are depicted as sticks. (B) Top view of the PDGF-B:PDGFRβ complex in surface representation.

    Platelet-Derived Growth Factor (PDGF) & Receptor References

      1. Matsui T, et al. (1989) Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243(4892): 800–4.
      2. Heidaran MA, et al. (1991) Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB. J. Biol. Chem. 266(30): 20232–7.
      3. Nobuo Jo, et al. (2006) Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. American Journal of Pathology. 168:2036-53.
      4. Ricardo H. et al. (2006) Biology of platelet-derived growth factor and its involvement in disease. Mayo Clinic Proceedings. 81(9): 1241-57.
      5. PengF, et al. (2008) Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. Eur J Neurosci. 28(7):1255-64.