Placental Lactogen (CSH1)

Placental Lactogen (CSH1) is produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. CSH1 does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Placental Lactogen (CSH1) Related Areas

 

Placental Lactogen (CSH1) Alternative Names

Placental Lactogen, CSH1, CSA, CSH2, CSMT, FLJ75407, PL, CS-1, hCS-A, lactogen, placental lactogen [Homo sapiens]

Summaries for Placental Lactogen (CSH1)

Entrez Gene summary for CSH1:

The protein encoded by this CSH1 gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

Wikipedia summary for Placental Lactogen:

Placental lactogen is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. Placental lactogen modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus.

Human Placental Lactogen (CSH1) Protein General Information

 

• Protein names: Placental lactogen
• Sequence length: 217 AA.
• Sequence similarities: CSH1 belongs to the somatotropin/prolactin family.
• Subcellular location: Secreted.
• Miscellaneous: The sequence of CSH1 is shown.

General information above from UniProt

Function for Placental Lactogen (CSH1) Protein

UniProtKB:

Placental Lactogen (CSH1) is produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. CSH1 does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Genatlas:

• CSH1 plays an important role in growth control

Homology for human Placental Lactogen (CSH1)

• homolog to C.elegans C17B7.12

Phenotype Information for Placental Lactogen (CSH1)

• Gene/Locus: CSH1, CSA, PL
• Phenotype: [Placental lactogen deficiency]

Phenotype Information for Placental Lactogen from OMIM (Online Mendelian Inheritance in Man)