Anti-Placental lactogen Antibody (Rabbit Polyclonal antibody) General Information
Anti-Placental lactogen Antibody
Reacts with: Human
Human Placental lactogen
Recombinant Human CSH1 protein (Catalog#11596-H08H)
Produced in rabbits immunized with purified, recombinant Human Placental Lactogen / CSH1 (rh Placental Lactogen / CSH1; Catalog#11596-H08H; NP_001308.1; Met1-Phe217). Placental Lactogen / CSH1 specific IgG was purified by Human Placental Lactogen / CSH1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Placental lactogen Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Placental lactogen Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human CSH1 in human placenta with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).Positive staining was localized to trophoblast.
Anti-Placental lactogen Antibody Alternative Names
Anti-CS-1 Antibody;Anti-CSA Antibody;Anti-CSMT Antibody;Anti-hCS-1 Antibody;Anti-hCS-A Antibody;Anti-PL Antibody
Placental lactogen Background Information
Chorionic somatomammotropin hormone, also known as Choriomammotropin, Lactogen, Placental lactogen and CSH1, is a secreted protein which belongs to the somatotropin / prolactin family. CSH1 is produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The CSH1 gene is member of the GH gene cluster on 17q, which consists of two growth hormone genes and three CSH genes. Genomic alterations in the GH cluster are well known, causing different phenotypes depending on the size of the deletion and the genes involved. The increased prevalence of hemizygosity of CSH1 in population in comparison to controls indicates a role for CSH1 haploinsufficiency in the etiology of growth retardation. Investigation of CSH1 deletions in further SRS and growth retarded patients will enable us to establish under which circumstances haploinsufficiency of CSH1 is likely to result in clinical changes.
chorionic somatomammotropin hormone 1 (placental lactogen)
Prager,S. et al., 2003,Genet Test. 7 (3):259-63. Singleton, DR. et al., 2004, Microbiology. 150 (Pt 2): 285-92. Chen,Y. et al., 2008, Cancer Res. 68 (23):9729-34.