Phospholipid Transfer Protein (PLTP)

Phospholipid transfer protein converts HDL into larger and smaller particles. PLTP may play a key role in extracellular phospholipid transport and modulation of hdl particles.

Phospholipid Transfer Protein (PLTP) Related Areas

Cardiovascular>>Lipid Metabolism>>PLTP

Phospholipid Transfer Protein (PLTP) Alternative Names

PLTP, HDLCQ9, lipid transfer protein II [Homo sapiens]

Pltp, RP23-61O3.5, OD107, lipid transfer protein II [Mus musculus]

Summaries for Phospholipid Transfer Protein (PLTP)

Entrez Gene summary for Phospholipid Transfer Protein (PLTP):

The protein encoded by PLTP gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for PLTP gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for Phospholipid Transfer Protein (PLTP):

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

Human Phospholipid Transfer Protein (PLTP) Protein General Information

 

• Protein names: Phospholipid transfer protein
  Short name=PLTP
• Sequence length: 493 AA.
• Domain: Signal
• Sequence similarities: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
• Subcellular location: Secreted.
• Tissue specificity: Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain.

General information above from UniProt

Function for Phospholipid Transfer Protein (PLTP) Protein

UniProtKB:

Phospholipid transfer protein converts HDL into larger and smaller particles. PLTP may play a key role in extracellular phospholipid transport and modulation of hdl particles.

Genatlas:

• Phospholipid transfer protein may play a key role in extracellular phospholipid transport
• Phospholipid transfer protein is involved in modulation of HDL particles (prebeta-HDL)
• Phospholipid transfer protein converts HDL into larger and smaller particles
• Phospholipid transfer protein is involved in cholesterol metabolism

Homology for human Phospholipid Transfer Protein (PLTP)

• homolog to murine Pltp (82.7 pc)
• homolog to rattus Pltp (82.1 pc)
• homolog to LBP,highly

Phenotype Information for Phospholipid Transfer Protein (PLTP)

• Gene/Locus: PLTP, HDLCQ9
• Phenotype: [High density lipoprotein cholesterol level QTL 9]

Phenotype Information for Phospholipid Transfer Protein (PLTP) from OMIM (Online Mendelian Inheritance in Man)