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Peroxiredoxin 6/PRDX6  Protein, Antibody, ELISA Kit, cDNA Clone

Peroxiredoxin 6/PRDX6 Related Area

Peroxiredoxin 6/PRDX6 Related Pathways

    Peroxiredoxin 6/PRDX6 Summary & Protein Information

    Peroxiredoxin 6/PRDX6 Background

    Gene Summary: The protein encoded by PRDX6 gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.; 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
    Subunit structure: Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B. {ECO:0000250, ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20716133}.
    Subcellular location: Cytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}.
    Sequence similarity: Belongs to the AhpC/TSA family. Rehydrin subfamily. {ECO:0000305}.; Contains 1 thioredoxin domain. {ECO:0000255|PROSITE-ProRule:PRU00691}.
    General information above from UniProt

    Peroxiredoxin 6/PRDX6 Alternative Name

    PRX,p29,AOP2,1-Cys,NSGPx,aiPLA2,HEL-S-128m, [homo-sapiens]
    PRDX6,1-Cys,aiPLA2,AOP2,KIAA0106,MGC46173,NSGPx,p29,Peroxiredoxin 6,PRX, [human]
    Prdx6,1-cysPrx,9430088D19Rik,AA690119,Aop2,Aop2-rs3,Brp-12,CP-3,GPx,KIAA0106,Ltw4,Ltw-4,Lvtw-4,Peroxiredoxin 6, [mouse]
    Aop2,CP-3,Ltw4,Ltw-4,NSGPx,ORF06,Prdx5,Brp-12,Lvtw-4,aiPLA2,1-cysPrx,AA690119,9430088D19Rik,GPx, [mus-musculus]

    Peroxiredoxin 6/PRDX6 Related Studies

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