Gene Summary: The protein encoded by PRDX6 gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]General information above from NCBI
Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Subunit structure: Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B.
Subcellular location: Cytoplasm. Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Also found in lung secretory organelles (By similarity).
Sequence similarities: Belongs to the AhpC/TSA family. Rehydrin subfamily.
Contains 1 thioredoxin domain.
General information above from UniProt