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Peroxiredoxin 5/PRDX5  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
  • Slide 1
100 µg 
20 µg 
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Description: Active  
Expression host: E. coli  
  • Slide 1
50 µg 
100 µg 
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Peroxiredoxin 5/PRDX5 Related Pathways

Peroxiredoxin 5/PRDX5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

Peroxiredoxin 5/PRDX5 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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Peroxiredoxin 5/PRDX5 Summary & Protein Information

Peroxiredoxin 5/PRDX5 Background

Gene Summary: PRDX5 gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for PRDX5 gene. [provided by RefSeq, Jul 2008]
General information above from NCBI
Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subunit structure: Monomer.
Subcellular location: Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.
Tissue specificity: Widely expressed.
Sequence similarity: Belongs to the peroxiredoxin 2 family.
Contains 1 thioredoxin domain.
General information above from UniProt

Peroxiredoxin-5, also known as Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5 and ACR1, is cytoplasm protein which belongs to the?peroxiredoxin 2 family. Peroxiredoxin-5 / PRDX5 reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-5 / PRDX5 is involved in intracellular redox signaling. The Peroxiredoxins / Prx are a family of 25 kDa peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups ( PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6 ) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

Peroxiredoxin 5/PRDX5 Alternative Name

PLP,ACR1,B166,PRXV,PMP20,PRDX6,prx-V,SBBI10,AOEB166,HEL-S-55, [homo-sapiens]
ACR1,AOEB166,B166,MGC117264,MGC142283,MGC142285,Peroxiredoxin 5,PLP,PMP20,PRDX5,PRDX6,PRXV,SBBI10, [human]
AOEB166,AOPP,Peroxiredoxin 5,Pmp20,Prdx5,Prdx6,PrxV, [mouse]
AOPP,PrxV,Pmp20,Prdx6,AOEB166, [mus-musculus]

Peroxiredoxin 5/PRDX5 Related Studies

  • Seo M.S., et al., 2000, J. Biol. Chem. 275: 20346-54.
  • Declercq J.-P., et al., 2001, J. Mol. Biol. 311:751-9.
  • Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90.
  • Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44.