Peroxiredoxin 2 (PRDX2)

Peroxiredoxin 2 is involved in redox regulation of the cell. Peroxiredoxin 2 reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. Peroxiredoxin 2 may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin 2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

Peroxiredoxin 2 (PRDX2) Related Areas

Enzyme>>Oxidoreductase>>Peroxiredoxin 2/PRDX2

Peroxiredoxin 2 (PRDX2) Alternative Names

Peroxiredoxin 2, PRDX2, MGC4104, NKEFB, PRP, PRX2, PRXII, TDPX1, TPX1, TSA, NKEF-B [Homo sapiens]

Peroxiredoxin 2, Prdx2, AL022839, Band-8, NkefB, PRP, PrxII, TDX1, TPx, TPx-B, TR, TSA, Tdpx1, Torin [Mus musculus]

Summaries for Peroxiredoxin 2 (PRDX2)

Entrez Gene summary for Peroxiredoxin 2 (PRDX2):

PRDX2 gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for PRDX2 gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for Peroxiredoxin 2 (PRDX2):

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.

Human Peroxiredoxin 2 (PRDX2) Protein General Information

 

• Protein names: Peroxiredoxin 2
  Short name=PRDX2
• Sequence length: 198 AA.
• Domain: Redox-active center
• Sequence similarities: Belongs to the AhpC/TSA family.
  Contains 1 thioredoxin domain.
• Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.
• Subunit structure: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
• Subcellular location: Cytoplasm.
• Miscellaneous: The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO₂H and Cys-SO₃H. Cys-SO₂H is retroreduced to Cys-SOH after removal of H₂O₂, while Cys-SO3H may be irreversibly oxidized.

General information above from UniProt

Function for Peroxiredoxin 2 (PRDX2) Protein

UniProtKB:

Peroxiredoxin 2 is involved in redox regulation of the cell. Peroxiredoxin 2 reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. Peroxiredoxin 2 may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin 2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H₂O₂.

Genatlas:

• Peroxiredoxin 2 may be playing an important role in eliminating peroxides generated during metabolism
• Peroxiredoxin 2 is involved in redox regulation of the cell
• Peroxiredoxin 2 reduces peroxides with reducing equivalents provided through the thioredoxin system
• Peroxiredoxin 2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
• Peroxiredoxin 2 enhances natural killer (NK) cells activity
• Peroxiredoxin 2 acts as a negative regulator of PDGF signaling
• Peroxiredoxin 2 has a role in both the resistance of certain cancers to therapy and quite a different role in possibly slowing the progression of neurodegenerative diseases
• Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte and having nonredundant role in erythrocyte defense against oxidative stress

Homology for human Peroxiredoxin 2 (PRDX2)

• homolog to yeast thioredoxin-dependent peroxide reductase (TPX)
• ortholog to Prdx2, Rattus norvegicus
• ortholog to Prdx2, Mus musculus
• homolog to drosophila Jafrac1
• ortholog to prdx2, Danio rerio
• ortholog to PRDX2, Pan troglodytes