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Peroxiredoxin 2/PRDX2 Protein, Antibody, ELISA Kit, cDNA Clone

Peroxiredoxin 2/PRDX2 Related Areas

Peroxiredoxin 2/PRDX2 Related Pathways

Peroxiredoxin 2/PRDX2 Related Product

    Peroxiredoxin 2/PRDX2 Summary & Protein Information

    Peroxiredoxin 2/PRDX2 Background

    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
    Subunit structure: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
    Subcellular location: Cytoplasm.
    Sequence similarity: Belongs to the AhpC/TSA family.
    Contains 1 thioredoxin domain.
    General information above from UniProt

    Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm protein which belongs to the ahpC / TSA family. Peroxiredoxin-2 / PRDX2 contains one thioredoxin domain. Peroxiredoxin-2 / PRDX2 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-2 / PRDX2 is not able to receive electrons from glutaredoxin. It may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-2 / PRDX2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

    The Peroxiredoxins / Prx are a family of peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups ( PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6 ) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

    Peroxiredoxin 2/PRDX2 Alternative Name

    MGC4104,NKEFB,NKEF-B,Peroxiredoxin 2,PRDX2,PRP,PRX2,PRXII,TDPX1,TPX1,TSA, [human]
    AL022839,Band-8,NkefB,Peroxiredoxin 2,Prdx2,PRP,PrxII,Tdpx1,TDX1,Torin,TPx,TPx-B,TR,TSA, [mouse]

    Peroxiredoxin 2/PRDX2 Related Studies

  • Cha M.-K., et al., 1995,  Biochem. Biophys. Res. Commun. 217:900-7.
  • Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90.
  • Chevallet M., et al., 2003, J. Biol. Chem. 278:37146-53.
  • Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44.
  • Gauci S., et al., 2009, Anal. Chem. 81:4493-501.