Anti-Peroxiredoxin 1 Antibody (Rabbit Polyclonal antibody) General Information
Anti-Peroxiredoxin 1 Antibody
Reacts with: Human
Human Peroxiredoxin 1
Recombinant Human Peroxiredoxin 1 / PRDX1 protein (Catalog#11194-H08E)
Produced in rabbits immunized with purified, recombinant Human Peroxiredoxin 1 / PRDX1 (rh Peroxiredoxin 1 / PRDX1; Catalog#11194-H08E; NP_002565.1; Met 1-Lys 199). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Peroxiredoxin 1 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Peroxiredoxin 1 Antibody Alternative Names
Anti-MSP23 Antibody;Anti-NKEF-A Antibody;Anti-NKEFA Antibody;Anti-PAG Antibody;Anti-PAGA Antibody;Anti-PAGB Antibody;Anti-PRX1 Antibody;Anti-PRXI Antibody;Anti-TDPX2 Antibody
Peroxiredoxin 1 Background Information
Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.
Neumann, CA. et al., 2003, Nature 424 (6948): 561-5 Gisin, J. et al., 2005, J Clin Pathol. 58 (11): 1229-31. Hoshino, I. et al., 2007, Oncol Rep. 18 (4): 867-71. Cao, J. et al., 2009, EMBO J. 28 (10): 1505-17.