Anti-Periostin Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human Periostin / POSTN / OSF-2 protein (Catalog#10299-H08H)
Produced in rabbits immunized with purified, recombinant Human Periostin / POSTN / OSF-2 (rh Periostin / POSTN / OSF-2; Catalog#10299-H08H; NP_001129407.1; Met 1-Gln 781). Periostin / POSTN / OSF-2 specific IgG was purified by Human Periostin / POSTN / OSF-2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Periostin Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Periostin Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human POSTN in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human POSTN in human colon with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human POSTN in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human POSTN in human breast carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Periostin Antibody Alternative Names
Anti-OSF-2 Antibody;Anti-OSF2 Antibody;Anti-PDLPOSTN Antibody;Anti-periostin Antibody;Anti-PN Antibody
Periostin Background Information
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced in areas of tissue injury or areas with ongoing cellular re-organization. In the adult heart Postn is induced in the ventricles following myocardial infarction, pressure overload stimulation, or generalized cardiomyopathy. Although the detailed function of Postn is still unclear, Postn-integrin interaction is thought to be involved in tumor development. Postn is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis, and can be a useful marker to predict the behavior of cancer.
periostin, osteoblast specific factor
Kudo,Y. et al., 2007, Histol Histopathol. 22 (10):1167-1174. Li, J.S. et al., 2007, World J Gastroenterol. 13 (39): 5261-5266. Oku, E. et al., 2008, Int J Hematol. 88 (1): 57-63. Hamilton, D.W. et al., 2008, J Cell Commun Signal. 2(1-2):9-17. Puglisi, F.J et al., 2008, Clin Pathol. 61 (4): 494-498. Conway, S. J. et al., 2008, Curr Genomics. 9 (8): 548-555.