Pepsinogen C / PGC Protein & Antibody

Pepsinogen C / PGC Products

Pepsinogen C / PGC Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Pepsinogen C/PGC	Human	Pepsinogen C/PGC Protein, Recombinant	12072-H08H
Pepsinogen C/PGC	Rat	PGC / pepsinogen C Protein,Recombinant	80097-R08H

  12072-H08H:  The specific activity is > 400 pmoles/min/µg. Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, R&D Systems, Catalog # ES005.

Pepsinogen C / PGC Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Pepsinogen C/PGC	WB, ELISA	Pepsinogen C / PGC Antibody (Antigen Affinity Purified)	12072-RP02
Human Pepsinogen C/PGC	WB, ELISA	Pepsinogen C / PGC Antibody	12072-MM07

Pepsinogen C / PGC cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Pepsinogen C/PGC	Human	Homo sapiens Pepsinogen C/PGC cDNA Clone	HG12072-G
Pepsinogen C/PGC	Mouse	SPINK4 cDNA Clone / ORF Clone	MG50953-G
Pepsinogen C/PGC	Rat	Pepsinogen C/PGC cDNA Clone / ORF Clone	RG80097-G

Pepsinogen C / PGC Related Areas

Enzyme>>Protease & Regulator>>Other Proteases & Regulators>>Pepsinogen C/PGC

Pepsinogen C / PGC Alternative Names

Pepsinogen C, PGC, progastricsin, RP11-298J23.1, FLJ99563, PEPC, PGII, gastricsin, pepsin C, pepsinogen group II, preprogastricsin [Homo sapiens]

Pepsinogen C, Pgc, progastricsin, 2210410L06Rik, MGC117575, Upg-1, Upg1, gastricsin, urinary pepsinogen 1 [Mus musculus]

PG1, Pg-1, Upg1 [Rattus norvegicus]

PGC Background

Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

PGC Related Studies

1. Richter C, et al. (1998) Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. Biochem J. 1 (335): 481-90.
2. Westerveld BD, et al. (1987) Gastric proteases in Barrett's esophagus. Gastroenterology. 93 (4): 774-8.
3. Ichinose M, et al. (1991) Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. Jpn J Cancer Res. 82 (6): 686-92.