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Pepsinogen C / PGC Antibody, Mouse MAb

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Human PGC Antibody Product Information
Immunogen:Recombinant Human Pepsinogen C / PGC protein (Catalog#12072-H08H)
Clone ID:4D7D1
Ig Type:Mouse IgG1
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Pepsinogen C / PGC (rh Pepsinogen C / PGC; Catalog#12072-H08H; NP_002621.1; Met 1-Ala 388). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human PGC Antibody IHC Application Image
Pepsinogen C / PGC Antibody, Mouse MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PGC in human stomach (from 3 donors) with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).
Other PGC Antibody Products
Reactivity: Human  
Application: ELISA  
    12072-RP02-50
    12072-RP02-200
    12072-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      12072-RP01-400
      12072-RP01-200
      12072-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      Reactivity: Rat  
      Application: ELISA  
        80097-R008-50
        80097-R008-100
        50 µg 
        100 µg 
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        Reactivity: Rat  
        Application: ELISA  
          80097-T16-50
          80097-T16-200
          80097-T16-100
          50 µg 
          200 µg 
          100 µg 
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          Reactivity: Rat  
          Application: ELISA  
            80097-RP01-400
            80097-RP01-200
            80097-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Pepsinogen C/PGC Background

            Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

            Human Pepsinogen C/PGC References
          • Richter C, et al. (1998) Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. Biochem J. 1 (335): 481-90.
          • Westerveld BD, et al. (1987) Gastric proteases in Barrett's esophagus. Gastroenterology. 93 (4): 774-8.
          • Ichinose M, et al. (1991) Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. Jpn J Cancer Res. 82 (6): 686-92.
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            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"