Parkinson's Disease Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
AGTR1/AT1	AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R	AGTR1/AT1 (Angiotensin II receptor, type 1) is an angiotensin receptor. It has vasopressor effects and regulates aldosterone  secretion. It is an important effector controlling blood pressure and volume  in the cardiovascular system.			HG10375-M
DOPA Decarboxylase	DDC, AADC	Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins. It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest.	10560-H08B		HG10560-M
AKT1					HG10763-M, HG10763-M
AKT1S1/PRAS40					HG10092-M
AKT2					HG10764-M
AKT3	DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2	V-akt murine thymoma viral oncogene homolog 3, also known as AKT3 and protein kinase B gamma (PKBγ), is a member of the AKT, also called PKB, serine/threonine protein kinase family. The members of AKT family are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).	10765-H09B		HG10765-M
IL-1 alpha	IL1F1, IL1A, IL-1A, IL1, IL1-ALPHA	Interleukin 1 (IL-1) is an important cytokine mediator involved in a variety of biological processes including immune responses, inflammatory, and promoting tissue degradation. IL-1 comprises two proteins, designated as IL-1 alpha and IL-1 beta which are encoded by distinct genes, and bind the same surface receptors with high affinity. Elevated levels of IL-1 alpha have been associated with a number of chronic disorders, including rheumatoid arthritis and Alzheimer’s disease, and therefore, may provide novel targets for therapeutic approaches aimed at controlling inflammatory processes.	10128-HNCH		HG10128-M, MG50114-M
IL-1 beta	IL1F2, IL1B, IL-1, IL1-BETA	Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 beta is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1  (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.	10139-HNAE		HG10139-M, MG50101-M
IL1F5					HG10125-M, MG50213-M
IL1F6					HG10607-M, MG50095-M
IL1F7					HG10155-M
IL1F8					HG10579-M
IL1F9					HG10124-M, MG50293-M
IL1F10					HG10122-M
LDL Receptor	LDLR, FH, FHC, LDLCQ2	LDLR is the prototype member of the LDLR family of scavenger receptors which is involved in receptor-mediated endocytosis of specific ligands.It functions as a receptor for extracellular Tat (HIV-1 transactivator) into neurons, mediating its internalization in uninfected cells. Mutations in LDLR gene cause the autosomal dominant disorder, familial hypercholesterolemia.	10231-H08H, 50305-M08H		HG10231-M, MG50305-M