>Pancreasin (Marapsin, PRSS27)
Pancreasin (Marapsin, PRSS27)
The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), which is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Pancreasin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. Pancreasin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.
Pancreasin ELISA Pair sets
Pancreasin cDNA Clones
Pancreasin, PRSS27, marapsin, NQ1884/PRO4327, CAPH2, MPN [Homo sapiens]
Pancreasin, Prss27, CAPH2, Mpn, marapsin [Mus musculus]
OMIM - description for Pancreasin:
Pancreasin is a pancreatic tryptic serine peptidase that cleaves peptides after an arginine residue.
Serine protease 27
Pancreasin belongs to the peptidase S1 family. Pancreasin contains 1 peptidase S1 domain.
Pancreasin is expressed predominantly in the pancreas.
General information above from UniProt
- Pancreasin is tryptic serine protease of the pancreas that cleaves peptides after an arginine residue
- Pancreasin acts as a serine-type endopeptidase
- homolog to rattus Mpn (75.8pc)
- homolog to murine Prss27 (77.5pc)
Drugs for Pancreasin from TTD (Therapeutic Targets Database)