Pancreasin / Marapsin Protein (PRSS27 Protein)

Protease, serine, 27

Pancreasin / Marapsin Products

Pancreasin / Marapsin Protein, Recombinant

Molecule	Species	Description	Cat. No
Pancreasin/Marapsin/PRSS27	Human	Pancreasin/Marapsin/PRSS27 Protein, Recombinant	12116-H08H

Pancreasin / Marapsin cDNA Clone

Molecule	Species	Description	Cat. No
Pancreasin/Marapsin/PRSS27	Human	Human Pancreasin/Marapsin/PRSS27 cDNA Clone / ORF Clone	HG12116-G

Pancreasin / Marapsin Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Trypsin / PRSS>>Pancreasin/Marapsin/PRSS27

Pancreasin / Marapsin Alternative Names

Pancreasin, PRSS27, marapsin, NQ1884/PRO4327, CAPH2, MPN [Homo sapiens]

Pancreasin, Prss27, CAPH2, Mpn, marapsin [Mus musculus]

Pancreasin / Marapsin Background

The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), which is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most strongly up-regulated protease in psoriatic lesions, where expression was localized to the upper region of the hyperplastic epidermis. Similarly, in the hyperproliferative epithelium of regenerating murine skin wounds, marapsin localized to the suprabasal layers, where keratinocytes undergo squamous differentiation. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.

Pancreasin / Marapsin Related Studies

1. Bhagwandin VJ, et al. (2003) Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 278(5): 3363-71.
2. Li W, et al. (2009) The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. J Biol Chem. 284(1): 218-28.