|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Pentraxin-Related Protein PTX3 Protein
PTX3 / TNFAIP5 / TSG-14 Protein Price Inquiry ( Available Sizes )
PTX3 / TNFAIP5 / TSG-14 Protein Product Information
PTX3, TNFAIP5, TSG-14
A DNA sequence encoding the human PTX3 ( NP_002843.2 ) ( Met 1 - Ser 381 ) was fused with a polyhistidine tag at the C-terminus
|Expression Host:||Human Cells|
PTX3 / TNFAIP5 / TSG-14 Protein QC Testing
|Purity:||> 97 % as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Glu 18|
The secreted recombinant human PTX3 consists of 375 amino acids and has a predicted molecular mass of 41.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 43 - 47 kDa.
|Formulation:||Lyophilized from sterile PBS , pH 7.4
PTX3 / TNFAIP5 / TSG-14 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
PTX3 / TNFAIP5 / TSG-14 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|PTX3/Pentraxin 3/TSG-14||Human||PTX3/Pentraxin 3/TSG-14 Protein, Recombinant||12082-H08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody||12082-RP01|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody (Antigen Affinity Purified)||12082-RP02|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody||12082-MM01|
PTX3 / TNFAIP5 / TSG-14 Protein Description
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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