>Rabbit PAb Antibody
>PTX3 / Pentraxin 3 / TSG-14 Antibody (Antigen Affinity Purified)
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PTX3 / Pentraxin 3 / TSG-14 Antibody ( Antigen Affinity Purified ) Datasheet
|Order or Inquire for PTX3 / Pentraxin 3 / TSG-14 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 2 ng/lane in WB|
|Detection limit is 0.00245 ng/well in ELISA|
PTX3 / Pentraxin 3 / TSG-14 Antibody Product Information
Recombinant Human PTX3 / Pentraxin 3 / TSG-14 protein (Catalog#12082-H08H)
|Antibody Type :||Rabbit Polyclonal Antibody ( Antibody Purification Platform )|
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
Produced in rabbits immunized with purified, recombinant Human PTX3 / Pentraxin 3 / TSG-14 (rh PTX3 / Pentraxin 3 / TSG-14; Catalog#12082-H08H; NP_002843.2; Met 1-Ser 381). PTX3 / Pentraxin 3 / TSG-14 specific IgG was purified by Human PTX3 / Pentraxin 3 / TSG-14 affinity chromatography.
PTX3 / Pentraxin 3 / TSG-14 Antibody Usage Guide
Human PTX3 / Pentraxin 3 / TSG-14
|Western blot :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PTX3 in WB. Using a DAB detection system, the detection limit for Mouse PTX3 is approximately 0.5 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.|
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PTX3. The detection limit for Mouse PTX3 is approximately 0.00245 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
PTX3 / Pentraxin 3 / TSG-14 Antibody Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|PTX3/Pentraxin 3/TSG-14||Human||PTX3/Pentraxin 3/TSG-14 Protein, Recombinant||12082-H08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody||12082-RP01|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody (Antigen Affinity Purified)||12082-RP02|
|Human PTX3/Pentraxin 3/TSG-14||WB, ELISA||PTX3 / Pentraxin 3 / TSG-14 Antibody||12082-MM01|
PTX3 / Pentraxin 3 / TSG-14 Antibody Background
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains onepentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
- Rolph MS. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5): e10-4.
- Mantovani A. et al., 2003, Vaccine. 21: S43-S47.
- Luchetti MM. et al., 2004, Clin Exp Rheumatol. 22 (3): S66-72.
- Mantovani A. et al., 2006, Vascul Pharmacol. 45 (5): 326-30.
- Inforzato A. et al., 2008, J Biol Chem. 283: 10147-61.
PTX3 (Pentraxin 3, TSG-14) related areas, pathways, and other information