PTX3 / Pentraxin 3 / TSG-14 Antibody (Cytokine)

Uteroglobin / SCGB1A1 Antibody ( Antigen Affinity Purified ) Datasheet

Uteroglobin / SCGB1A1 Antibody Product Information

• Immunogen: Recombinant Human Uteroglobin / SCGB1A1 protein (Catalog#10808-H08H)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Human Uteroglobin / SCGB1A1 (rh Uteroglobin / SCGB1A1; Catalog#10808-H08H; P11684; Met 1-Asn 91). Uteroglobin / SCGB1A1 specific IgG was purified by Human Uteroglobin / SCGB1A1 affinity chromatography.

Uteroglobin / SCGB1A1 Antibody Usage Guide

• Specificity: Human Uteroglobin / SCGB1A1
• Western blot: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SCGB1A1 in WB. Using a DAB detection system, the detection limit for Human SCGB1A1 is approximately 0.5 ng/lane under non-reducing conditions and 4 ng/lane under reducing conditions.
• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SCGB1A1. The detection limit for Human SCGB1A1 is approximately 0.00975 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Uteroglobin / SCGB1A1 Antibody Background

Uteroglobin (UG), or Secretoglobin 1A member 1 (SCGB1A1), a protein belongs to the secretoglobin family. Uteroglobin/SCGB1A1 also known as Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is a small molecular weight secreted protein found only in mammals, and mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory / immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The mechanism (s) of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

References

1. Laukaitis CM. et al., 2005, Biological Journal of the Linnean Society. 84 (3): 493-501.
2. Klug J. et al., 2000, Ann N Y Acad Sci. 923: 348-54.
3. Kido T. et al., 2011, Am J Physiol Lung Cell Mol Physiol. 300 (3): L441-52.
4. Mukherjee AB. et al., 2007, Endocr Rev. 28 (7): 707-25.
5. Mukherjee AB. et al., 1999, Cell Mol Life Sci. 55 (5): 771-87.