Anti-TCPTP Antibody

Cat: 50800-T16
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Anti-TCPTP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TCPTP Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse TCPTP
Immunogen
Recombinant Mouse PTPN2 / TC-PTP protein (Catalog#50800-M07B)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse PTPN2 / TC-PTP (rh PTPN2 / TC-PTP; Catalog#50800-M07B; Q06180-1; Ser2-Asn314). PTPN2 / TC-PTP specific IgG was purified by Mouse PTPN2 / TC-PTP affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TCPTP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TCPTP Antibody Alternative Names
Anti-AI325124 Antibody;Anti-Ptpt Antibody;Anti-TC-PTP Antibody
TCPTP Background Information

Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Full Name
protein tyrosine phosphatase, non-receptor type 2
References
  • Cool D., et al.,(1989), cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc. Natl. Acad. Sci. U.S.A. 86:5257-5261.
  • Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
  • Nusbaum C., et al.,(2005), DNA sequence and analysis of human chromosome 18.Nature 437:551-555.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TCPTP Antibody Rabbit Polyclonal WB,ELISA,IP 50800-T52
    Anti-TCPTP Antibody Rabbit Monoclonal ELISA 50800-R001
    Anti-TCPTP Antibody Rabbit Polyclonal ELISA 50800-RP01
    Anti-TCPTP Antibody Rabbit Polyclonal ELISA,IHC-P 10570-T24
    Anti-TCPTP Antibody Rabbit Polyclonal WB,ELISA,IP 10570-T52
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