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PTPN2/TC-PTP Rabbit PAb , Antigen Affinity Purified

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    Mouse PTPN2 Antibody Product Information
    Immunogen:Recombinant Mouse PTPN2 / TC-PTP protein (Catalog#50800-M07B)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse PTPN2 / TC-PTP (rh PTPN2 / TC-PTP; Catalog#50800-M07B; Q06180-1; Ser2-Asn314). PTPN2 / TC-PTP specific IgG was purified by Mouse PTPN2 / TC-PTP affinity chromatography.
    Other PTPN2 Antibody Products
    PTPN2/TC-PTP Background

    Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

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