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PTP1B Protein, Antibody, ELISA Kit, cDNA Clone

PTP1B Protein, Antibody, ELISA Kit, cDNA Clone Products

With multiple advanced technology platforms and large scale capacities, Sino Biological has quickly emerging as a leader of life science research tool developer worldwide. All our proteins are manufactured in bulk quantities using sequence verified vectors and state-of-the-art mammalian, insect, or E. coli expression processes. We are adding more than 800 proteins per year, of which "hot" proteins are high on the priority list, such as H1N1 antigens and antibodies that we offered.

Sino Biological Inc offers quality PTP1B Protein, Antibody, ELISA Kit, cDNA Clone Products for research .

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PTP1B Protein, Antibody, ELISA Kit, cDNA Clone

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Summary of PTP1B Protein, Antibody, ELISA Kit, cDNA Clone

PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. It has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to interferon stimulation.

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