PTP1B / PTPN1 Protein

Protein Tyrosine Phosphatase 1B / Protein Tyrosine Phosphatase, Non-receptor type 1

PTP1B / PTPN1 Products

PTP1B / PTPN1 Protein, Recombinant

Molecule	Species	Description	Cat. No
PTP1B/PTPN1	Human	PTP1B/PTPN1 Protein, Recombinant	10304-H07E

PTP1B / PTPN1 cDNA Clone

Molecule	Species	Description	Cat. No
PTP1B/PTPN1	Human	Homo sapiens PTP1B/PTPN1 cDNA Clone	HG10304-M

PTP1B / PTPN1 Related Areas

Enzyme>>Phosphatase & Regulator>>PTP1B/PTPN1

Signal Transduction>>Phosphatase & Regulator>>PTP1B/PTPN1

PTP1B / PTPN1 Alternative Names

PTP1B, PTPN1 [Homo sapiens]

PTP1B, Ptpn1, RP23-58A8.1, PTP-1B, PTP-HA2 [Mus musculus]

PTP1B / PTPN1 Background

PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. It has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to interferon stimulation.

PTP1B / PTPN1 Related Studies

1. Frangioni JV, et al. (1992) The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell. 68(3):545-60.
2. Zhu S, et al. (2007) PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. Cancer Res. 67(21):10129-37.
3. Aoki N, et al. (2000) A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J Biol Chem. 275(50):39718-26.
4. Stuible M, et al. (2008) PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem. 283(23):15740-6.
5. Ravichandran LV, et al. (2001) Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. Mol Endocrinol. 15(10):1768-80.