PTK6 / BRK Protein

Protein Tyrosine Kinase 6 / Breast Tumor Kinase

PTK6 / BRK Products

PTK6 / BRK Protein, Recombinant

Molecule	Species	Description	Cat. No
PTK6/BRK	Human	PTK6/BRK Protein, Recombinant, With GST Tag	10682-H09B

  10682-H09B:  The specific activity of PTK6 was determined to be 48 nmol / min / mg. The specific activity of PTK6 was determined by using a Poly (Glu:Tyr, 4:1) synthetic peptide substrate.

PTK6 / BRK cDNA Clone

Molecule	Species	Description	Cat. No
PTK6/BRK	Human	Homo sapiens PTK6/BRK cDNA Clone(NM_005975.2)	HG10682-M
PTK6/BRK	Mouse	Mouse PTK6/BRK cDNA Clone / ORF Clone	MG50710-M

PTK6 / BRK Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>PTK6/BRK

Cancer>>Cancer Biomarkers>>PTK6/BRK

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>PTK6/BRK

PTK6 / BRK Alternative Names

PTK6, BRK, FLJ42088 [Homo sapiens]

Ptk6, BRK, Sik, Tksk, tks [Mus musculus]

PTK6 / BRK Protein Background

Tyrosine kinase (PTKs) is a protein that carry out tyrosine phosphorylation, which play a fundamental role in cell proliferation, survival, adhesion, and motility and have also been demenstrated to mediate malignant cell transformation. Overexpression of this protein in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Two classes of PTKs are present in cells: the transmembrane receptor PTKs and the non-receptor PTKs. Tyrosine kinase(PTKs)-6/ BRK is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Tyrosine kinase(PTKs)-6/ BRK has been shown to undergo autophosphorylation. It has been found that the constitutive expression of the tyrosine kinase(PTKs)-6/ BRK is in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations. State BRK expression was also induced in normal T-cells. In clinical, the cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis.

PTK6 / BRK Protein Related Studies

1. Aubele M, et al. (2008) Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.British Journal of Cancer. 99: 1089-95.
2. Kasprzycka M, et al. (2006) Expression and oncogenic role of Brk (PTK6/sik) protein tyrosine kinase in lymphocytes. American Journal of Pathology. 168: 1631-41.
3. Hubbard SR, et al. (2000) Protein tyrosine kinase structure and function. Annual review of biochemistry. 69: 373-98.