All PTH1R reagents are produced in house and quality controlled, including 3 PTH1R Antibody, 15 PTH1R Gene, 1 PTH1R Lysate, 1 PTH1R Protein, 1 PTH1R qPCR. All PTH1R reagents are ready to use.
Recombinant PTH1R proteins are expressed by HEK293 Cells with fusion tags as C-His.
PTH1R antibodies are validated with different applications, which are ELISA, IHC-P.
PTH1R cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PTH1R of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).
Schipani E., et al., 1993, Endocrinology 132:2157-2165.
Hopyan S., et al., 2002, Nat. Genet. 30:306-310.
Bastepe M., et al., 2004, J. Clin. Endocrinol. Metab. 89:3595-3600.
Duchatelet S., et al., 2005, Hum. Mol. Genet. 14:1-5.
Decker E., et al., 2008, Am. J. Hum. Genet. 83:781-786.