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PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified

  • PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human PTH1R Antibody Product Information
Immunogen:Recombinant Human PTH1R / PTHR1 protein (Catalog#12232-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human PTH1R / PTHR1 (rh PTH1R / PTHR1; Catalog#12232-H08H; Q03431; Met 1-Gly 188). PTH1R / PTHR1 specific IgG was purified by Human PTH1R / PTHR1 affinity chromatography.
Human PTH1R Antibody IHC Application Image
PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PTH1R in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PTH1R in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
PTH1R / PTHR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human PTH1R in human mammary adenocarcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other PTH1R Antibody Products
PTH1R/PTHR1 Background

Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).

Human PTH1R/PTHR1 References
  • Schipani E., et al., 1993, Endocrinology 132:2157-2165.
  • Hopyan S., et al., 2002, Nat. Genet. 30:306-310.
  • Bastepe M., et al., 2004, J. Clin. Endocrinol. Metab. 89:3595-3600.
  • Duchatelet S., et al., 2005, Hum. Mol. Genet. 14:1-5.
  • Decker E., et al., 2008, Am. J. Hum. Genet. 83:781-786.
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