Anti-PTH1R Antibody

Cat: 12232-RP02
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Anti-PTH1R Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PTH1R Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human PTH1R
Immunogen
Recombinant Human PTH1R / PTHR1 protein (Catalog#12232-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human PTH1R / PTHR1 (rh PTH1R / PTHR1; Catalog#12232-H08H; Q03431; Met 1-Gly 188). PTH1R / PTHR1 specific IgG was purified by Human PTH1R / PTHR1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PTH1R Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PTH1R Antibody (Rabbit Polyclonal antibody) Images
Human PTH1R/PTHR1 Immunohistochemistry(IHC) 3718
Immunochemical staining of human PTH1R in human mammary adenocarcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human PTH1R/PTHR1 Immunohistochemistry(IHC) 3719
Immunochemical staining of human PTH1R in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human PTH1R/PTHR1 Immunohistochemistry(IHC) 3720
Immunochemical staining of human PTH1R in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-PTH1R Antibody Alternative Names
Anti-MGC138426 Antibody;Anti-MGC138452 Antibody;Anti-PFE Antibody;Anti-PTHR Antibody;Anti-PTHR1 Antibody
PTH1R Background Information

Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).

Full Name
parathyroid hormone 1 receptor
References
  • Schipani E., et al., 1993, Endocrinology 132:2157-2165.
  • Hopyan S., et al., 2002, Nat. Genet. 30:306-310.
  • Bastepe M., et al., 2004, J. Clin. Endocrinol. Metab. 89:3595-3600.
  • Duchatelet S., et al., 2005, Hum. Mol. Genet. 14:1-5.
  • Decker E., et al., 2008, Am. J. Hum. Genet. 83:781-786.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PTH1R Antibody Rabbit Polyclonal ELISA 12232-RP01
    Anti-PTH1R Antibody Rabbit Monoclonal ELISA 12232-R003
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