|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Homo sapiens prostaglandin D2 synthase 21kDa (brain) DNA.|
|PDS, PGD2, PGDS, LPGDS, PGDS2, L-PGDS, PTGDS|
|Identical with the Gene Bank Ref. ID sequence.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||HG13346-G-F|
|Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||HG13346-G-H|
|Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||HG13346-G-M|
|Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||HG13346-G-N|
|Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||HG13346-G-Y|
|Product name||Product name|
PTGDS, also known as L-PGDS, belongs to the calycin superfamily，lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.