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    PTGDS / L-PGDS

    PTGDS / L-PGDS Protein & Antibody

    Entrez Gene Summary for PTGDS / L-PGDS


    The protein encoded by this PTGDS gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PTGDS functions as a neuromodulator as well as a trophic factor in the central nervous system. PTGDS is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This PTGDS gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

    OMIM-Description for PTGDS / L-PGDS


    Prostaglandin D2 (PGD2) functions as a neuromodulator and/or trophic factor in the central nervous system. Glutathione (GSH)-independent PGD synthase catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2 in the presence of various sulfhydryl compounds. The enzyme is responsible for biosynthesis of PTGDS in the brain (Nagata et al., 1991).

    Wikipedia Summary for PTGDS / L-PGDS


    Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.
    The protein encoded by this PTGDS gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This PTGDS gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).

    PTGDS / L-PGDS Altermative Names

    PTGDS / L-PGDS Related Products

    PTGDS / L-PGDS Proteins

    Product nameProduct name
    Human PTGDS / L-PGDS Protein (His Tag)

    PTGDS / L-PGDS Antibodies

    Product nameProduct name

    PTGDS / L-PGDS cDNA Clones

    Product nameProduct name
    Human PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHuman PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, His-taggedHuman PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-taggedHuman PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHuman PTGDS Gene cDNA Clone (full-length ORF Clone), expression ready, HA-taggedHuman PTGDS Gene cDNA Clone (full-length ORF Clone)

    PTGDS / L-PGDS ELISA

    Product nameProduct name
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"