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PTGDS / L-PGDS

PTGDS / L-PGDS Protein & Antibody

Entrez Gene Summary for PTGDS / L-PGDS


The protein encoded by this PTGDS gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PTGDS functions as a neuromodulator as well as a trophic factor in the central nervous system. PTGDS is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This PTGDS gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

OMIM-Description for PTGDS / L-PGDS


Prostaglandin D2 (PGD2) functions as a neuromodulator and/or trophic factor in the central nervous system. Glutathione (GSH)-independent PGD synthase catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2 in the presence of various sulfhydryl compounds. The enzyme is responsible for biosynthesis of PTGDS in the brain (Nagata et al., 1991).

.zh=PTGDS / L-PGDS


Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.
The protein encoded by this PTGDS gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This PTGDS gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).

PTGDS / L-PGDS Alternative Names

PDS,LPGDS,PGDS2,L-PGDS,PGD2,PGDS, [homo-sapiens]
PGD2,PGDS,prostaglandin-H2 D-isomerase,beta-trace protein,cerebrin-28,glutathione-independent PGD synthase,glutathione-independent PGD synthetase,lipocalin-type prostaglandin D synthase,LPGDS,L-PGDS,PDS,PGD2 synthase,PGDS2,prostaglandin D synthase,prostaglandin-D2 synthase,RP11-229P13.6, [human]
prostaglandin-H2 D-isomerase,21kDa,brain),glutathione-independent PGD synthase,glutathione-independent PGD synthetase,lipocalin-type prostaglandin-D synthase,L-PGDS,PGD2,PGD2 synthase,PGDS,PGDS2,prostaglandin D2 synthase (21 kDa,prostaglandin-D2 synthase,Ptgs3,RP23-47P18.11-006, [mouse]
PGD2,PGDS,PGDS2,Ptgs3,L-PGDS,21kDa, [mus-musculus]

PTGDS / L-PGDS Related Products

PTGDS / L-PGDS Proteins

Product nameProduct name
Human PTGDS / L-PGDS Protein (His Tag)

PTGDS / L-PGDS Antibodies

Product nameProduct name
PTGDS / L-PGDS Antibody, Rabbit PAbPTGDS / L-PGDS Antibody, Rabbit PAb, Antigen Affinity Purified

PTGDS / L-PGDS cDNA Clones

Product nameProduct name
Human PTGDS ORF mammalian expression plasmid, N-HA tagHuman PTGDS ORF mammalian expression plasmid, C-HA tagMouse PTGDS ORF mammalian expression plasmid, C-Myc tagHuman PTGDS ORF mammalian expression plasmid, C-OFPSpark / RFP tagHuman PTGDS ORF mammalian expression plasmid, C-His tagRhesus PTGDS ORF mammalian expression plasmid, C-GFPSpark tagRhesus PTGDS natural ORF mammalian expression plasmidHuman PTGDS ORF mammalian expression plasmid, N-Flag tagRat PTGDS ORF mammalian expression plasmid, N-Flag tagRat PTGDS Gene cDNA clone plasmidMouse PTGDS ORF mammalian expression plasmid, N-Myc tagHuman PTGDS ORF mammalian expression plasmid, C-Flag tagRhesus PTGDS ORF mammalian expression plasmid, N-Myc tagMouse PTGDS natural ORF mammalian expression plasmidHuman PTGDS natural ORF mammalian expression plasmidMouse PTGDS ORF mammalian expression plasmid, N-His tagRhesus PTGDS ORF mammalian expression plasmid, N-His tagRat PTGDS ORF mammalian expression plasmid, C-Flag tagRat PTGDS ORF mammalian expression plasmid, C-Myc tagRat PTGDS ORF mammalian expression plasmid, C-OFPSpark / RFP tagRat PTGDS ORF mammalian expression plasmid, C-GFPSpark tagRat PTGDS natural ORF mammalian expression plasmidRhesus PTGDS Gene cDNA clone plasmidHuman PTGDS ORF mammalian expression plasmid, N-Myc tagMouse PTGDS ORF mammalian expression plasmid, C-GFPSpark tagMouse PTGDS ORF mammalian expression plasmid, C-OFPSpark / RFP tagRhesus PTGDS ORF mammalian expression plasmid, N-Flag tagRhesus PTGDS ORF mammalian expression plasmid, C-Myc tagHuman PTGDS ORF mammalian expression plasmid, N-His tagRhesus PTGDS ORF mammalian expression plasmid, C-OFPSpark / RFP tagMouse PTGDS ORF mammalian expression plasmid, C-HA tagHuman PTGDS ORF mammalian expression plasmid, C-GFPSpark tagRhesus PTGDS ORF mammalian expression plasmid, N-HA tagRat PTGDS ORF mammalian expression plasmid, N-Myc tagRat PTGDS ORF mammalian expression plasmid, C-His tagRhesus PTGDS ORF mammalian expression plasmid, C-HA tagHuman PTGDS Gene cDNA clone plasmidMouse PTGDS ORF mammalian expression plasmid, N-HA tagMouse PTGDS ORF mammalian expression plasmid, C-His tagMouse PTGDS ORF mammalian expression plasmid, N-Flag tagRhesus PTGDS ORF mammalian expression plasmid, C-His tagHuman PTGDS ORF mammalian expression plasmid, C-Myc tagMouse PTGDS ORF mammalian expression plasmid, C-Flag tagRat PTGDS ORF mammalian expression plasmid, N-HA tagMouse PTGDS Gene cDNA clone plasmidRat PTGDS ORF mammalian expression plasmid, C-HA tagRat PTGDS ORF mammalian expression plasmid, N-His tagRhesus PTGDS ORF mammalian expression plasmid, C-Flag tag

PTGDS / L-PGDS ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"